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A selective enrichment of AR binding sites at distinct chromosomal regions could yield direct biologically relevant information on prostate cancer progression and may uncover drivers in ADT resistance.
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This might reflect redundancy among the distinct target genes of each isoform, or among their distinct binding sites at common target genes.
It was already reported that genes having more distinct miRNA binding sites at the 3′UTR regions tend to have slower evolutionary rates [ 9].
If K+ and Mg2+ act by binding to a distinct binding site at the surface or in a more buried location, this site would be additional to that which binds Na+ selectively.
a, 2mFo−DFc electron density map (blue mesh) of residues around the methylguanidinium binding site at 1σ. b, Overlay of guanidinium binding site (green) and methylguanidinium binding site (orange).
We find that human and chimp FOXP2 have similar binding sites that are distinct from previously suggested consensus binding sites.
Our computational bioinformatics analysis revealed that the variation at the 5′ end of the gene predicted altered transcription factor binding creating or deleting putative binding sites for five distinct transcription factors.
This may be possible by modulating receptors using allosteric ligands, which interact with the receptor at a binding site topographically distinct from the endogenous ligand.
These results suggest that AAL binds to the N-terminal fructosyl valine at a binding site distinct from that of l-fucose.
They must ensure that the conjugation of the radiochelate is outside of the target binding site or at a distinct site known not to affect antigen binding.
We have first extracted genome-wide distributions of five HATs [namely, p300, CBP, MOF (males absent on the first; KAT8), PCAF, and Tip60) and 18 acetylation marks and then systematically analysed the presence of each of the 18 acetylation marks at the binding sites of the five distinct HATs.
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