Sentence examples for binding sites as seen from inspiring English sources

In IκBβ, the NLS polypeptide binds to two binding sites, as seen in the crystal structure, with one site heavily favored for stable binding.

Homeotypic clusters of binding sites, as seen in developmental genes in Drosophila melanogaster [ 20], represent one regulatory mechanism that could explain the occurrence of long, conserved non-coding regions.

Interestingly, alkali and earth alkali ions rather stimulate protease activity at distinct binding sites, as seen for the prominent examples of Na+ with thrombin [115 117] or Ca2+ with trypsin [118,119].

The proportion of shuffled sets in which we saw an equal or higher number of predicted transcription factor (TF) binding sites as seen in the real data provides an estimate of how likely the observed number of matrix matches would be seen by chance in sequence of similar nucleotide composition.

This effect was partly attributed [22] to a more labile water molecule that binds site I Ca2+ (the left binding site, as seen in Figures 6).

On the other hand, Ror2 autoinhibition combines several elements; its activation loop occludes the substrate- and ATP-binding sites as seen in IRK, but with additional unique contributions from a tyrosine side chain close to the gatekeeper residue.

As shown in Figure 3, backbone and/or side-chain atoms in the region following the DFG (Asp-Phe-Gly) motif occlude the phosphate-binding site, as seen in particular for Met and Ser of TrkA and Leu of Ror2.

Apart from the primary site, our goal was to find other, prerequisite binding sites, as well.

The presence of the phenylpropyl moiety increased activity significantly against the enzyme (cf. 6 and 7; 5 and M), suggesting that the phenylpropyl moiety has an interaction in the binding site, as has been previously seen in the polyamine class of inhibitors.

Here we built a multivariate regression model to infer activity changes of TFs beyond copy number and methylation status variations using TF binding sites as features (see Methods).

Moreover, both AR proteins exhibit substantial cooperativity between binding sites, again as seen for GR and PR.