Sentence examples for binding sites as identified from inspiring English sources

It is more efficient than the commonly-used luciferase assay and can be used to confirm the candidate binding sites as identified by other tools.

To investigate further potential explanations for the increased HBD2 production in response to LPS in CD and UC but not HC, we sequenced the promoter region of the DEFB4 gene, to ask whether IBD patients had polymorphisms at potential NF-κB binding sites, as identified by Transcriptional Element Search Software (TESS) [38].

Indeed, GATA3 binding sites as identified by ChIP-seq are predominantly enriched in intergenic regions.

The mechanism(s) for resistance to catalytic kinase inhibitors, however may more likely relate to mTOR mutations within the ATP binding site as identified for imatinib and gefitinib.

In the case of hTFIIEα AC-D, its binding site as identified here (residues 378 395) is consistent with the previous report that a deletion mutant of hTFIIEα, Δ377 393 could no longer bind to hTFIIH, whereas a mutant with residues 351 439 could bind (Ohkuma et al, 1995).

Recently, ChIP-chip and ChIP-sequencing experiments have been accumulated to identify TF binding sites as well as survey the chromatin modification patterns at the regulatory elements such as promoters and enhancers.

This review gives an overview of mutagenesis studies that have led to the development of a model of the ATP binding site, as well as identifying residues contributing to allosteric regulation and antagonism.

Interaction and colocalization of phosphoT130-cdc25C with Plk1 demonstrate in living cells, that the sequence around pT130 acts as a true Polo Box Domain (PBD) binding site as previously identified from in vitro peptide screening studies.

The sensitivity (i.e. the fraction of simulated binding sites identified) as well as the positive predictive value (i.e. the accuracy of the target sites identified) of the scored results was computed using the simulated data.

We used those CTCF binding sites as surrogates both to identify constitutive CTCF loci and to identify, for other proteins, their constitutive loci that overlapped with constitutive CTCF loci.

This offers the possibility to rate the confidence levels of the identified objects according to these values and, using a stringent threshold value, validates subsets of the identified binding sites as strong evidence.