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Table 5 lists miRNAs whose binding sites are underrepresented in 3'UTRs of eIF4E upregulated mRNAs.
Another miRNA whose binding sites are underrepresented on eIF4E responsive mRNAs is miR-27b that is often decreased in breast cancer tissues and functions as a negative regulator of CYP1B1, a protein whose genotype correlates with prostate cancer risk [45].
Conversely, KLF4 binding sites are underrepresented in the LPS-induced cluster 2. Although the KLF2 chip-on-chip dataset available was relatively small, several KLF2 targets were regulated by Dex and contained GR binding sites, including Klf2 itself, Klf4, Klf9 and Tgfb3 [ 37].
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Thus, young and old plausible NAGNAG sites are underrepresented in ordered regions, indicating that selection against such sites is universal and more effective over large evolutionary distances.
For 13 of them corresponding sites are underrepresented in only 9.5%% (4 of 42 cases) strains without the R-M system.
Surprisingly, the locations of these dmCpG sites are underrepresented in promoter regions and are overrepresented in the middle and 3′ ends of genes.
As anticipated, CpG sites are underrepresented in viral genomes, although to a lesser extent than in their human host genome [ 17, 20].
We present multiple lines of evidence that such tandem sites are underrepresented in protein-coding sequences (CDS), and in particular in regions that form ordered 3D protein structures.
Small MAG-CP sites were underrepresented at site visits, and for each KT method, most respondents were from large perinatal centres.
This site is underrepresented in most genomes (38 of 42) where corresponding methyl-directed R-M systems are encoded.
This bias may be due to the use of EcoRI for cloning or may reflect the presence of genomic regions in which the EcoRI site is underrepresented.
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