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53% of CUX1 binding sites are located more than 4,000 bp away from a TSS and approximately 14% of all CUX1 binding sites are situated at more than 40,000 bp from a TSS.
Genome-wide location analysis on the ENCODE array revealed that ~47% of CUX1 binding sites are located in the 4-Kbp region upstream and downstream of a TSS, while more than 14% of CUX1 binding sites are situated at more than 40 Kbp from a TSS.
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Yet, over 6% and 8% of binding sites were situated at more than 40,000 bp upstream or downstream, respectively, from the closest TSS.
The model suggests that a high affinity cocaine binding site is situated in a region of the model where Asp98 acts like an anchor, while a putative low affinity site is situated in another region with Glu508 as the anchoring amino acid.
On the basis of the TAM equilibrium binding studies, it was not possible to determine whether, for the singly occupied enzyme, the high-affinity TAM binding site is situated on the subunit that is bound to PAPS.
XBP consists of two similar globular domains that are connected by a flexible hinge region, where the d-xylose binding site is situated at the interface between the two domains.
Most sites are situated on dunes, cover sands or edges and slopes of river terraces.
Most eccentric sites are situated in the larger territories in northern Flanders.
Two of the sites are situated in wetlands (Oldenburg and Wolkenwehe).
2. Only a few sites are situated in the hyper-arid zone in the southern Negev.
The less coloured sites are situated at the furthest distance from obstacles.
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