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Two binding sites are separated into two disjoint enriched regions by PICS, whereas MACS [5] combined these two sites into a single region.
A Monte-Carlo assessment further confirmed that the enrichment of paired PPARγ/RXR binding sites is significant at FDR<0.05 when these bona fide individual binding sites are separated by <300 bp (Figure 3C).
The binding sites are separated by 30 or 29 nucleotides in the promoters of E spl) genes of Drosophila melanogaster and higher vertebrates, respectively [ 33, 34].
The crystal structure of the fiber-knob protein shows that the three known sialic acid binding sites are separated by distances of about 10 Å.
Alternatively, after linker ligation, the DNA could be redigested with an endonuclease that cuts within the flanking plasmid DNA so that the primer binding sites are separated on different molecules (see [257]).
The active sites of each noncrystallographic pair of subunits (A B and A′ B′) are connected by an internal cavity or tunnel, and the substrate binding sites are separated by about 35 Å.
Similar(52)
In this case, the reaction mixtures of limiting antibody and excess total PSA were only seven seconds old and far from equilibrium when the antibody molecules with unoccupied binding sites were separated from the reaction mixture and quantified using the immobilized PSA.
Typically NFAT- and AP-1-binding sites are separated by seven or less nucleotides.
Interestingly, degenerate selection experiments for TAL1 binding in vitro have identified a composite E-box/Gata motif where the two DNA-binding sites are separated by 8 10 bp (Wadman et al, 1997).
Lac repressor binding site was separated from the 601NPE by 10 bp.
Therefore, we have conducted an additional experiment on a template where the Gal4 binding site was separated from the 601NPE by 24 bp.
More suggestions(15)
binding sites are assessed
binding sites are extracted
binding lobes are separated
binding sites are characterized
binding sites are identified
binding sites are given
binding sites are indicated
binding sites are shared
binding sites are maintained
binding sites are assumed
binding motifs are separated
binding sites are juxtaposed
binding sites are underrepresented
binding sites are presented
binding sites are listed
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