Sentence examples for binding sites are necessary from inspiring English sources

19 It can be used as a phasing tool and only a few binding sites are necessary, whereas mononuclear heavy atoms must bind to multiple sites to provide useful phases, especially for large proteins.

In Xenopus embryos adjacent Pum1 and CUGBP1 binding sites are necessary to achieve spatially regulated translation of the xCR1 mRNA [50].

None of the constructs responded to CPT (figure 6 C), suggesting that both binding sites are necessary for the transcriptional induction of COQ7 in response to CPT.

A set of motifs consisting of the ZESTE, GAF/PSQ and PHO/PHOL binding sites are necessary, but not sufficient for PRE function [ 37].

We next investigated whether the predicted nuclear receptor binding sites are necessary for CRM activity by mutating the predicted binding motifs for NR in two enhancers, CG17298 and CG4998.

It has been shown that multiple shared transcription factor binding sites are necessary for co-expression to occur and that there is a positive correlation in sequence similarity and co-expression [ 16].

These results suggest that both the C2 domain and the PDZ binding site are necessary for efficient membrane localization.

Under these conditions, the fluorescence intensity of the electrodes (Supporting Figure 2) is approximately the same as that measured on the electrode functionalized only with PPy, indicating that free biotin-binding sites are necessary for SA to bind to the PPy-biotin film and confirming the low level of nonspecific adsorption.

The C-terminal Gly and a l-amino acid analogue at the Cys binding site were necessary for inhibition, suggesting that human GGT was highly selective for glutathione (γ-Glu-l-Cys-Gly), whereas E. coli GGT are not selective for glutathione, but still retained the dipeptide (l-AA-Gly) binding site.

These results suggest that the p300-2 binding site is necessary for the basal and UV-induced tregulationofal regulation of MMP-1.

HKIII is primarily expressed in the lung, kidney, and liver [7], [9], [41], and an Oct-1 binding site is necessary for basal HKIII expression [9], but little else is known about the regulation of HKIII activity.