Sentence examples for binding sites are more from inspiring English sources
On the other hand, many tyrosine kinases (including the well-known Src family kinases) and adaptor molecules have both SH2 and SH3 domains, and it has been suggested that proteins containing multiple SH3 binding sites are more likely to be tyrosine phosphorylated and bind to SH2 domains as supported by biochemical studies [ 10, 11].
Intuitively, SNPs within regions of strong conservation or strong natural selection or microRNA binding sites are more likely to affect the disease predisposition.
In fact, using the average constraint score per base pair as a metric, the IREs and STAT binding sites are more conserved than Agrp coding sequences in this alignment of species (Table 2).
Based on the phylogenetic tree, we applied MONKEY [56] to get the significance that each putative binding sites are more conserved among the three species than their flanking sequences.
Such nucleosome-mediated cooperativity has been observed in other contexts [22], [23], and it is known that cis-regulatory elements occurring within clusters of transcription factor binding sites are more likely to be functional in vivo [24].
Because evolutionarily conserved sites may be more functional than nonconserved sites [51], [52], this observation suggests that the tissue-specific binding sites are more likely to be functional than the binding sites that are shared in multiple tissues.
Taken together, these suggest that DNA duplex stability data should be informative of binding sites; whether a lower or higher DNA duplex stability at specific TF binding sites is more preferable depends largely on the binding preference of the TF, that is, whether the TF binds to the the DNA in a double- or single-strand manner.
The distribution of TypeII (PACAP/VIP) binding sites is more restricted than that of typeI binding sites, and are located in the olfactory bulb, the cerebral cortex, the dentate gyrus of the hippocampus, thalamus, the locus coeruleus of the pons, area postrema, and the spinal cord [46 50].
In general, high-confidence CRMs (STAT binding sites) were more conserved than intermediate-confidence sites.
These binding sites were more conserved and located closer to TSSs than those whose function was not experimentally verified [18].
