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The TF binding sites are mapped onto the mm8 (February 2006) mouse assembly.
Interestingly, binding sites are mapped only in the intergenic regions (between rpmH– dnaA, dnaA– dnaN, yqeG– sda, ywlB– ywlC, jag– thdF, yycS– yydA, ywcI– vpr, and gcp– ydiF).
When transcription factor binding sites are mapped on gene promoter regions, the anchoring transcriptional start site forms a separating point as shown in Figure 2. Upstream of the transcriptional start site, occurrence frequency of binding sites goes up, whereas the frequency is reduced downstream of the start site.
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AR binding sites were mapped to transcriptional start sites (TSS) of genes based on refFlat (hg19) table from UCSC Genome Browser.
When AR binding sites were mapped to genomic annotations, they appeared only moderately associated with proximal promoters, with approximately 2 fold over-representation compared to genomic background (Additional file 3: Table S1).
Transcription factor binding sites were mapped within hotspots using the P-Match program available from TRANSFAC [52].
The nucleotide modifications (by DMS), the pauses corresponding to nuclease (TI and VI) cleavage sites and the toe prints corresponding to PTB binding sites were mapped to MFOLD predicted structure for clarity (Fig. 3).
Using synthetic α-actinin-4 peptides, HAMLET binding sites were mapped to the N-terminal actin-binding domain and the proposed β integrin-binding central rod domain between spectrin repeats 1 and 2, suggesting that HAMLET might impair these essential interactions, [5], [6], [10].
Ribosome binding sites were mapped when possible according to the sequence described in reference [ 41].
Sox2 stable binding sites were mapped by low-excitation 2D single molecule imaging condition (Video 7 ).
In the first step, putative TF binding sites were mapped in the DNA sequence of enhancers and controls.
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binding sites are associated
binding sites are found
binding sites are known
binding sites are indicated
binding sites are observed
binding sites are overrepresented
binding sites are enriched
binding sites are detected
binding sites are represented
binding sites are formed
binding sites are occupied
binding sites are blocked
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