Sentence examples for binding sites are important from inspiring English sources
Others have shown that the two p53 binding sites are important for p21Waf1/CIP1 transcription and we have found the same requirement in differentiating keratinocytes (Figure S3).
However, it has been shown that both the location and combination of different binding sites are important for promoter recognition [5], [6].
We found that Sp1 binding sites are important both for basal and hyperosmolarity-induced promoter activities, whereas the NF-κB binding site plays an important role in the hyperosmolarity-induced promoter activity.
Remarkably, the combined mutation of the three intragenic AP-1 binding sites decreased by ∼ two fold the PMA-mediated RNAPII in vivo recruitment to the viral promoter (Fig. 7B, left panel), thereby supporting the notion that the 5103 fragment AP-1 binding sites are important for HIV-1 transcriptional activity.
Because microRNA binding sites are important for mRNA translation and degradation, the variant T allele of rs2016347 might disturb binding to this microRNA site [ 34].
The conservation of promoters and transcription factor (TF) binding sites are important predictors of gene expression similarity, and there is a correlation between conservation of TF binding events and conservation of the target gene expression (Hemberg and Kreiman, 2011).
We next asked whether the spacing between the two core binding sites was important for FOXP3 DNA binding.
Although individual ascites volumes had no major impact on the variability (data not shown), the number of available binding sites was important.
These data suggest that the region −116 to + 36, which includes evolutionarily conserved predicted transcription factor binding sites, is important for basal transcription of ALMS1.
