Sentence examples for binding sites are found from inspiring English sources
The rarity of correspondingly stable fragments in natural proteins coupled with the observation that high quality ribosome binding sites are found to occur within E. coli protein-coding regions significantly less often than expected by random chance implies a stringent evolutionary pressure against protein sub-fragments that can independently fold into stable structures.
Ligand-binding sites are usually found in deep protein surface cavities, but it should be emphasized that not all binding sites are found in deep cavities.
In contrast, the STAT1 pathway and thus STAT1 binding sites are found in species as distant as insects.
Interestingly, Table S4 shows that CREB transcription binding sites are found to be over-represented in upregulated genes, while they are clearly under-represented in the downregulated genes.
STAT binding sites are found in two clusters, one cluster in proximal enhancers, which show embryonic expression and second cluster in distal enhancers, which show adult expression (Supplementary data Figure S6).
The NR4A2 transcription factor gene is a particularly striking example as it displays highly complex differential expression in PFO and PT areas and layers (Figures 5,6), and for which higher divergence of binding sites are found in several target genes showing differential expression in the same regions (File S1).
All these binding sites were found within regulatory regions including upstream of promoters, promoters, and 5′-proximal to coding regions (Supplementary Table 1).
Many binding sites were found to shift dramatically between embryos and starved larvae, from developmentally regulated genes to genes involved in metabolism.
