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When DNA binds, two identical octahedral metal binding sites are formed between the MBD and RHH domains (4).
The Scatchard plot analysis demonstrates that two classes of binding sites are formed with the equilibrium dissociation constants.
However, their Le epitope binding sites are formed by one or two amino acids.
In particular, the long-held belief that agonist binding sites are formed only at α interfaces has been challenged by increasing evidence for a viable agonist binding site at α interfaces.
The 5-HT3 receptor belongs to a family of therapeutically important neurotransmitter-gated receptors whose ligand binding sites are formed by the convergence of six peptide loops (A-F).
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Scatchard plot analysis revealed that two classes of imprinted binding sites were formed in the imprinted polymer.
One of those additional binding sites is formed by the region around Cys60 (which is the cysteine responsible for the dimerization (see above), and it is the predicted interaction site with NTR [71]); furthermore, the majority of those other four additional sites involve the hydrophobic side chains of several lysine residues present in PsTRXf and not in the other two proteins (Fig. 1).
Finally, a third method of incorporating pharmacophores into virtual screening is to add constraints to the docking run to ensure that certain interactions between the ligands and the target binding site are formed.
Firstly, protein interface zinc-binding sites are formed between the Fab1 and Fab2 molecules and involve the tetravalent coordination by Fab residues (Fig. 3 A and C).
Uniquely among the family of glutamate ionotropic receptors, NMDA receptors require both glutamate and glycine (a co-agonist) to bind to the receptor for channel activation to occur with the glycine binding site being formed by the S1 and S2 domains of the GluN1 subunit and glutamate binding site being formed from the homologous regions on the GluN2 subunit.
BBL becomes ordered on biotin binding and then adenylate binding site is formed in EcBirA.
More suggestions(19)
binding sites are listed
binding sites are provided
binding sites are compared
binding sites are paired
binding sites are predicted
binding sites are assessed
binding sites are extracted
binding sites are proposed
binding sites are characterized
binding sites are identified
binding sites are mapped
binding sites are given
binding sites are shared
binding sites are maintained
binding sites are assumed
binding sites are juxtaposed
binding sites are located
binding sites are underrepresented
binding sites are presented
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