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In the case of hemoglobin, all binding sites are equivalent, so there is only one sub-group of binding sites containing four elements.
In a similar manner, the case in which all binding sites are equivalent [ 7] can be seen as a special case, in which there is only one sub-group of identical binding sites.
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The binding site is equivalent to an antibody with respect to the surface area.
Cadmium-mycophosphatin has an isoelectric point less than pH 2, binds cadmium with a dissociation constant of KD = 1.59 X 10 M (pKD = 6.8) and is saturated with 13.5 mole Cd/mole, all Cd-binding sites being equivalent.
Our MD simulations and MM-PBSA calculations suggest that the two K+ binding sites are not equivalent and the lower binding site is energetically favorable.
We can again distinguish between R and T state, which yields: If we now assume that the n ligand binding sites are, in general, non-equivalent, we must account for the fact that R i is a collection of protein molecules in the R state with all possible combinations of i out of n ligand binding sites occupied.
Functional TF binding sites are likely to be situated in conserved non-coding regions, and furthermore, to be located in equivalent positions across genomes [ 12].
On the other side of the spectrum, when networks are not sparse, and the spontaneous gain rate of binding sites is relatively equivalent to their loss rate, selecting on a specific pathway function does not affect regulatory complexity.
Peaks for residues at known RING binding sites are shown: I6 in helix 1, K63 in loop 4, L97 in loop 7; C85 is the active site Cys; I88 undergoes allosteric changes upon RING binding; L103 is present in helix 2.(C) Combined 1H and 15N chemical shift perturbations of 0.18 mM 15N-UbcH5a at 0.9 molar equivalents of RNF125stop129.
Twelve binding sites are present within the dodecameric channel.
[3H]nicotine binding sites are associated with mammalian optic nerve terminals.
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