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Exact(3)
Conversely, distant binding sites are assumed to have highly distinct binding properties.
SNPs with high conservation scores, high positive selection scores, or within microRNAs' target binding sites are assumed to have higher disease risk [8], [9], [10], [11].
The most commonly used method is a log-odds approach in which the frequencies of bases in the binding sites are assumed to be proportional to their contributions to binding affinity [9], [22].
Similar(57)
The two agonist binding sites were assumed to be equivalent and independent [37] and the interval durations at all three concentrations were fitted together by using a C↔AC↔A2C↔A2O kinetic model (A = agonist) that had four rate constants as free parameters: single-site association (k+, scaled by [A]), single-site dissociation (k−), ko, and kc.
Gelatinase binding sites were assumed to be within the rigid triple-helical collagen structure and thus far have been described only at the oligopeptide level [ 7, 16].
In fitting all three data sets, a single binding site was assumed on VCA.
The dissociation of stable complex between transcription factor and binding site was assumed to be slow and was modelled by a stochastic transition with a relative rate of 10/a.u.u
The speed of a TF's binding to or dissociation from its target sites is assumed to be much more rapid than the transcription process, thus rapid-equilibrium approximation can be used.
In addition to indicating that simple PWM scanning might be as accurate (at least in yeast) as PMM scanning, the accuracy of PMM scanners at predicting the known binding sites was orders of magnitude less than it should theoretically be, assuming that binding sites are not lost and that the multiple alignments are reasonably accurate.
It is assumed that the stronger binding sites are occupied first and that the binding strength decreases with the increasing degree of site occupation.
It has to be noted that the predicted binding sites are indeed cis-acting elements (CAE), which is assumed as TFBS and MBS, respectively.
More suggestions(14)
binding sites are observed
binding sites are required
binding sites are conserved
binding sites are represented
binding sites are identified
binding sites are found
binding sites are indicated
binding sites are predicted
binding sites are occupied
binding sites are shown
binding sites are detected
binding sites are enriched
binding sites are given
binding sites are associated
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