Sentence examples for binding sites and key from inspiring English sources

Li X, Fleetwood AD, Bayas C, Bilwes AM, Ortega DR, Falke JJ, Zhulin IB, Crane BR, "The 3.2 Å resolution structure of a receptor: CheA CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays," Biochemistry.

Ligand binding sites and key catalytic residues are structurally conserved, strongly implicating LsrF as a class I aldolase.

The high mutation rate and exposed structure of the P2 domain of the capsid protein has led to the assumption that receptor binding sites and key antigenic determinants are localised in this region [24], [25].

We also identify the consensus DNA-binding motif found in all the GlnR binding sites and determine key nucleotides in the motif for specific GlnR binding.

Selection of optimal binding sites and design features of nanocarriers are key controllable factors that can be iteratively engineered based on their performance from in vitro to pre-clinical in vivo experimental models.

We hypothesize that this stability is achieved by a combination of both local purifying selection on key CTCF binding sites and by buffering of major topological loops by additional factors.

Many CNEs may contain regulatory factor binding sites, and their frequent spatial association with key developmental genes – such as those regulating sensory system development – suggests crucial roles in regulating gene expression and cellular patterning.

SO mapped transcription start sites, used site-directed mutagenesis and ChIP assays to identify key transcription factor binding sites and helped to identify signalling pathways associated with the regulation of promoter activity.

The regulation of the mechanical stability of GB1 by IgG fragments is not through direct modification of the interactions in the mechanically key region of GB1; instead, it is accomplished via the long-range coupling between the IgG binding site and the mechanically key region of GB1.

The most potent 9b, 9c, 9e compounds shared common active site with the Lisinopril binding site and retained the key active site residue interactions.

The combination group also showed high methylation levels at all CpG sites at the second analysis, with the exception of −444 bp and −433 bp, which were near the NF-κB binding site and is the key region involved in the transcriptional regulation of miR-146a [ 22, 23].