Sentence examples for binding sites and active from inspiring English sources

The identification of binding sites and active sites in proteins is therefore an important aid to interpreting the effects of mutations.

This movement is reminiscent of the aromatic gates that control access of ligands to substrate binding sites and active sites as discussed for acetylcholinesterase and membrane transport channels.

The annotations of binding sites and active sites in Swiss-Prot [ 92], the main database with hand-curated annotations of protein characteristics, provide a combination of experimental information and patterns of conservation of key regions.

For the remaining introns, His-Cys box motifs, zinc binding sites and active sites were only verified when frame-shifts corrections were manually inserted in silico, or were absent.

His-Cys box motifs, zinc binding sites and active sites were characterized on intron-coding complementary strands for six PSA individuals from three different populations (Haplotypes H2, H4 and H5, Table 3, Figure 2).

For example, the presence of binding sites and active sites imposes a strong constraint on the variability of sequences that is difficult to separate from the purely structural one.

First, piET improved the identification of the known DNA binding site and active site of LexA.

We also show that Y80 and D117 are required for the communication between the DCA-binding site and active site of PDHK2.

Alternatively, the variation observed at the P+1 pocket may reflect the unique mode of allosteric coupling between the substrate-binding site and active site in CMGC kinases.

In the inactive state, the conserved region must form base pairs with any regions from the helical arms II (helix II) until the hairpin loops next to the helix (includes both effector binding sites), and in the active state, this conserved region must be unpaired and the overall structure must have three helices [39, 40] that resembles the conformation of an active hammerhead ribozyme.

These dramatic changes in the binding sites and at the active site were not clearly observed in Dpo4 and reflect the nature of the binding interface in the pol β DNA complex.