Sentence examples for binding sites activated by from inspiring English sources

In total, 377 HIF-1 binding sites activated by hypoxia were identified across the genome.

Its signalling pathways are relatively well understood with tyrosine residues Y1175 and Y1214 in the human VEGFR2 being the main auto-phosphorylation sites activated by VEGF binding and tyrosine kinase activation.

Remarkably a common enrichment for SP1 binding sites was found in genes containing at least one or two high score TFAP2A binding sites and transcriptionally activated by TFAP2A but not in the repressed ones.

The approach proved to be very useful in the study of large families of enzymes/receptors which hold higly similar binding sites or are activated by the same substrate/ligand.

In contrast, luciferase reporter constructs containing NFAT or AP1 binding sites were readily activated by treatment with PROK1 (p < 0.05; Fig. 2C).

The effect was specific, as transfection of the FopFlash reporter vector containing mutated LEF/TCF binding sites was not activated by β-catenin (Additional file 1: Figure S4).

In C2C12 cells, the construct containing all three putative CREB binding sites was activated 6.4-fold more by wild-type CREB than inactive mutant CREB.

A second SAM molecule, thought to bind at the same binding site, is then activated by the reduced [4Fe-4S] clustor to generate a dAdo radical.

TIGAR-hBS2, the more efficient of the two human p53-binding sites, is efficiently activated by either human or mouse p53.

Thus, three Mirk promoter constructs, each only containing the exon 4 CREB binding site, were activated ~6-fold by wild-type CREB compared with mutant CREB.

Each of these p53-binding site reporters were activated by both human and mouse p53.