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We hypothesized that placing the alkyne at the entrance of the pocket, distal from the core pharmacophore binding site, would reduce the steric interference with ligand binding when conjugated to the fluorophore.
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Our results suggest that the absence of the SP1 DNA binding site would impair or reduce the transcription activity of the SPP1 promoter.
A protein binding site would be an attractive hypothesis.
A defined consensus sequence for the AtoC binding site would greatly facilitate the identification of potential AtoC binding elements.
Using isolated TREs rather than TH-responsive promoters substantially reduced the complexity that multiple binding sites would present.
The binding sites would not only reveal mRNA targets but would show GQ motif consensus if that's really the in vivo binding site for Aven.
Using the same amplifying strategy as before the H2-binding site would also be present offering a second binding site.
Perhaps a more plausible cap-binding site would be located in the conserved Ago 5' guide RNA binding pocket.
Chaperone binding would reduce aggregate formation and promote refolding.
When the bioflavonoid concentration becomes too high, it will increase the fraction of the active peroxidase site that is still occupied by the reducing co-substrate, and when this occurs, it would inhibit the binding of PGG2 to the peroxidase site and thus would reduce the catalytic activity of the enzyme for the formation of further products.
This intervention would increases the mucin crosslinking binding sites to reduce the aerosolizability on mucus simulants (surrogate of transmissibility), and/or forming poorly soluble mucin complexes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com