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Conservation in location of YY1 binding site would indicate conservation of the encoded dipeptide motif whereas a lack of conservation in motif location is consistent with selection for the presence of the motif at the DNA level.
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A protein binding site would be an attractive hypothesis.
Using the same amplifying strategy as before the H2-binding site would also be present offering a second binding site.
Black arrows indicate residues that form the guanidinium binding site, blue arrows indicate the hydrophobic constriction site and red arrows indicate the conserved intracellular negative cluster.
The crystal structure shows Trp237 present in the peptide and 2-OG binding site, indicating binding of ligands would affect tryptophan fluorescence.
Genomic sequences of the shared binding regions associated with expressed genes were analyzed for presence of an E-box consensus site on the sense or antisense strand (5'-CANNTG-3'), which would indicate a potential Twist1 binding site.
The orientation of CTAP revealed that if extended to generate the larger CAP molecule, blockade of the coreceptor binding site (indicated in gray in Fig. 7) [ 15] and the V3 loop (indicated in yellow in Fig. 7) would result.
(D ) Close-up of the MELTP binding site indicating the role of ScBub1R314 in MELTP binding.
In an epitope mapping effort, the preferred binding site of selected Affibody ligands was mapped to amino acids 30 36 of Aβ, which fortunately would indicate that the Affibody molecules should not bind the amyloid precursor protein (APP).
The translocation of CoA between the two binding sites is indicated by the red arrow.
Residues that form each of the HBGA binding sites are indicated.
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