Sentence examples for binding site would be from inspiring English sources

In any case, internally over-stabilized conformations generated in the conformational search would be less suitable as pose candidates, since their ability to form directional intermolecular H-bonding or hydrophobic interactions within the binding site would be compromised.

The kinetics data implied that residues 113 and 219 can regulate the affinity of the substrate and ATP molecule but do not contribute directly to the catalysis of DNA polymerization, suggesting that the ATP binding site would be distinct from the catalytic site for DNA polymerization.

A protein binding site would be an attractive hypothesis.

Should the third not actually be a transmembrane helix, the ATP binding site would be located intracellularly rather than extracellularly.

Improved compounds, derived from our Sirt2 inhibitors or identified through docking more drug-like compounds to their putative binding site, would be helpful for functional studies and promising for therapy.

Accessibility of RNase II to its binding site would be dependent on a conformational change induced by RhlB binding and, perhaps to a lesser extent, by PNPase binding to the RNaseE scaffold domain.

Accordingly, considering the previous section, the ALK and MET ATP binding sites would be expected to appear similar to each other than to EGFR, with the EGFR-T790M mutants somewhere in between.

In different tissues, with distinct chromatin accessibility profiles, different binding sites would be occupied.

This means that a substantial proportion of potential binding sites would be lost by depending on one algorithm in isolation.

Deletion and mutation analysis of Rad promoter revealed that potential Egr-1 binding sites would be critical for PDGF-induced Rad expression.

In this study, we examined whether the sequences around the different categories of murine PPARγ and/or RXR binding sites would be conserved in the human.