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Under the "Target View", the click on "Design MREs" button a of any sequences having the conserved binding site will open a "Show mutation" window.
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Specification of the drug binding site will result in docking around the given three-dimensional coordinate.
The interface at blocked and closed states could be identified from the models, and based on the expectation that all myosin binding sites will be accessible to the myosin head in the open state (M-state), we find that zone 2 will be more favourable for Tm interaction.
NCaBD containing two Ca2+ binding sites will need to be fit with a two binding site model.
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