Sentence examples for binding site will be from inspiring English sources
However, our docking model was insufficient to specifically identify VDR antagonists and thus, further investigation using ensemble docking (i.e., combinatorial docking using diverse series of conformations for antagonists as well as a collection of different conformations for the VDR binding site) will be necessary to better account for the flexibility of the binding site.
Whether such mixed effects are related to the nature of the binding site will be the subject of our further studies.
The observed events in the apo form simulation (i.e., the cytoplasmic end closing and extracellular end opening) may facilitate the transporter to rearrange its conformation so that the extracellular substrate binding site will be accessible for the substrate.
Furthermore, ChromAnalyzer HMM scans are meant to be an iterative process: each newfound, validated COUP-TFI DNA binding site will be incorporated into the HMM training list, and thus the COUP-TF HMM parameters will be fine-tuned to reflect the exact profile of the known COUP-TF binding sites.
Since no MEIS1 is expressed in the embryonic heart, enhancers containing the de novo binding site will be recovered by ChIP using an NKX2-5 antibody.
When this fusion protein is expressed in cells, the adenines in the DNA adjacent to its binding site will be methylated.
Our hypothesis is that if the TF is active in a tissue, it will bind a number of target sequences, thus the putative TF binding sites will be overrepresented in the DNase HS regions (see Methods for details).
This information regarding the binding sites will be useful for designing a new class of diuretics or anti-hypertensive agents that inhibit the interaction of ClC-K and barttin.
Further biochemical characterization of a larger number of binding sites will be required for a more elaborate sequence alignment.
In this way, TALE-TF binding sites will be in optimal position for transcriptional activation (within 200 bp upstream of transcription start sites).
The integration of predicted miRNA and small RNA target sites with transcription factor binding sites will be useful for AthaMap-assisted gene expression analysis.
