Sentence examples for binding site which was from inspiring English sources
Docking results suggested that compounds C2 and C22 could not only efficiently fit into the catalytic site of the HPTPβ enzyme but also interact with the Lys1807, Arg1809 and Lys1811 residues of the secondary binding site, which was next to the catalytic center of the enzyme.
The MMP1-1959luc construct includes the p300-2 binding site, which was essential for UV-induced increase of MMP-1 promoter activity as described above.
At pH 5.6, the GlcNAc binding site is dislocated and the cis-Asp282-Cys283 peptide bond near the binding site, which was observed at pH 7.0 in the crystal structure, shows a trans conformation, suggesting a pH-sensitive region in the ligand-binding site of the M-ficolin [6], [23].
Furthermore, we detected a potential remote binding site which was previously identified in other kinases.
Hence, the putative transcription factor binding site which was previously described by Lesnik and coworkers (2005) [ 13] was removed.
Within the first 1600 bp, we identified one putative binding site, which was located between −94 bp and −117 bp from the transcriptional start of the caspase-1 gene.
In contrast to its congeners, 11 binds upside down in the binding site which is a much poorer binding pose.
The free energy landscape showed favorable free energies at the periplasmic opening and the internal binding site, which were separated by a 20 ± 5 kJ/mol barrier (Fig. 5A,B) and an associated binding free energy of -24 ± 10 kJ/mol, which is in excellent agreement with the experimental binding free energy of −23 kJ/mol24.
This would only be correct if the antagonist and the agonist have the same binding site, which is unclear.
Patients with prostate, ovary, and skin cancer may develop auto-antibodies to the alpha(2)M* binding site which are receptor agonists whose presence indicates a poor prognosis.
In addition to predictive power, MD simulations of multiple RT mutants are providing fundamental insight into the dynamics of the allosteric NNRTI binding site which is useful for the design of future inhibitors.
