Sentence examples for binding site which involves from inspiring English sources

Assuming the proposed extended mainly positively charged polySia binding site which involves N-terminally located residues such as Arg73 and Lys95, the N-terminal poly-ψ-domain might contribute to polySia binding by forming an extension of the acceptor binding site.

Taken together, our data imply that Asn, Arg and Ser are important for directing AR-C155858 to its final binding site which involves interaction of the inhibitor with Lys, Asp and Phe (residues that also play key roles in the translocation cycle) and also Leu and Ser.

Compared to the human enzyme (hG6PD), the 3D model has enabled the identification of a key difference in the substrate-binding site, which involves the replacement of Arg365 in hG6PD by Asp750 in PfG6PD.

The HV region in the S-domain of SRKs acts as the SCR-binding site, which involves a two-stage recognition process [ 45].

However, SwissDock also predicted a quinidine-binding site, which involved pore-lining residues F304, I308 and V312.

Here we demonstrate the engineering of a Zn2+ binding site at the predicted dimeric interface of the dopamine transporter (DAT) corresponding to the external end of transmembrane segment 6. Upon binding to this site, which involves a histidine inserted in position 310 (V310H) and the endogenous Cys306 within the same DAT molecule, Zn2+ potently inhibits [3H]dopamine uptake.

SNP11 is located at the GATA3 binding site, which is involved strongly in Th2 differentiation [ 43].

One of the 15°C-hypermethylated CpGs was located in a TAF (putative TATA box binding protein associated factor) binding site, which is involved in establishing the transcription initiation factor TFIID multimeric protein complex and plays a central role in mediating promoter responses to activation and repression.

Moreover, structural considerations suggest the existence of a secondary, putative low-affinity binding site (LBS) located in a positively charged region close to the AdoMet binding site which could be involved in binding the capped RNA substrate (Egloff et al., 2007; Mastrangelo et al., 2007a; Dong et al., 2008; Bollati et al., 2009a,b).

This region contains one methylated SRE element and one SP1 binding site, which are well-known transcription factors involved in the regulation of lipogenic genes such as ELOVL6 [ 1, 2, 14, 42].

The apoA-I promoter has a C/EBP binding site, which suggests C/EBP- β could be involved in the production of apoA-I.