Sentence examples for binding site which are from inspiring English sources
Regions of the binding site which are common within a protein family can be identified and analysed for the design of family-targeted libraries or those which differ for improvement of ligand selectivity.
Patients with prostate, ovary, and skin cancer may develop auto-antibodies to the alpha(2)M* binding site which are receptor agonists whose presence indicates a poor prognosis.
The promoter region contains many conserved motifs, including an ASF1 motif (important for auxin- and salicylic acid-inducible transcription), an LS10-like motif, and many W-box motifs (potential WRKY transcription factor binding site), which are found in promoter of other PR-1 genes (Table 1).
There exist two Cys and one Met residues on protein binding site, which are potential stabilizing residues of peptide binding.
After 5 min incubation time (Figure 3B), features appeared at the MMP-9 binding site which are assigned to the formation of a small area of denatured collagen.
Residues in the binding site, which are exposed but under functional selective pressure, show an intermediate rate.
In contrast to its congeners, 11 binds upside down in the binding site which is a much poorer binding pose.
The free energy landscape showed favorable free energies at the periplasmic opening and the internal binding site, which were separated by a 20 ± 5 kJ/mol barrier (Fig. 5A,B) and an associated binding free energy of -24 ± 10 kJ/mol, which is in excellent agreement with the experimental binding free energy of −23 kJ/mol24.
This would only be correct if the antagonist and the agonist have the same binding site, which is unclear.
In addition to predictive power, MD simulations of multiple RT mutants are providing fundamental insight into the dynamics of the allosteric NNRTI binding site which is useful for the design of future inhibitors.
The best docked conformation of compound 5l predicted by MOE showed that the compound is deeply inserted within the urease binding site which is further stabilize by multiple hydrophilic and hydrophobic interactions, contributing to the higher activity of this compound.
