Sentence examples for binding site where the from inspiring English sources

The majority of ligands described to date bind at two main regions of the 5-HT3R: the orthosteric binding site (where the native agonist binds) and the channel.

A recent study using a quantitative fluorescence titration technique showed that Pol X binds gapped DNA in two distinct modes: one utilizing the total DNA binding site of Pol X and the other utilizing only the auxiliary DNA binding site where the enzyme binds to the double-stranded region of the DNA (28).

Our calculations are based on only the need for a perfect match at the 3' end of the primer for PCR to occur, assuming that a homologous site already exists within an amplifiable distance from the other primer binding site where the primer can bind in the reverse direction.

Most of missing and weaker NH signals should be due to the paramagnetic effect of the [2Fe-2S] cluster, as they are from residues located around the CGFS active site and/or the GSH binding site, where the [2Fe-2S] cluster is presumably coordinated by the active site cysteines and the two GSH cysteines (Fig. 2F).

This point is emphasised for the common conformation d-band binding site, where the collagen monomers have much less contact with decorons LRR's 2 through 8 (the central section), than at the e1-band receptor site.

As reported by Artoni et al. [45] 7E3's binding site was mapped between the C177-C184 loop and W129 residue in human β3 integrin subunit, in a region that is spatially close to the β3 subunit MIDAS (metal-ion dependent binding site), where the Asp residue of the RGD motif is also known to bind.

The principle is to employ vector constructs that harbour multiple miRNA binding sites where the miRNA of interest can bind to and thus is not any more available to bind its targets.

The calorimetric data reveals the presence of two sequential nature of binding sites where the first binding site has stronger affinity (~ 104 M− 1) and second binding site has weaker affinity (~ 103 M− 1).

One calpain substrate is the giant sarcomeric protein titin, which contains high-affinity calpain binding sites where the protein can be cleaved [25, 26].

Carbohydrate groups and so-called V loops on gp120 appear to partly cover and obscure the binding sites where the protein attaches to both CD4 and another receptor, called CCR5.

Protein kinases can also be inhibited by competition at the binding sites where the kinases interact with their substrate proteins, and most proteins are present inside cells at concentrations much lower than the concentration of ATP.