Sentence examples for binding site were mutated from inspiring English sources

Three nucleotides in the core sequence of putative NF-κB binding site were mutated (GGG changed to CTC, Fig. 2B).

Several residues lining the putative binding acyl chain binding site were mutated to purturb substrate binding.

Residues N71, Q104, and S192, which are located around the Pc binding site, were mutated to cysteine.

This inhibition response was abolished when miR-29 binding site was mutated, since this mutation (pLuc-3URTmutant-p85) prevents miR-29 binding to targets in the mRNA.

Luciferase reporters were constructed containing either wild-type full-length Gli1 3′UTR (pMIR/Gli1) or a mutated Gli1 3′UTR (pMin/Gli1/mut, in which the sequence of the putative miR-133b binding site was mutated).

a, The p63 binding site was mutated using CRISPR Cas9 and homology-directed repair techniques to disrupt p63 binding (p63BSPM).

On the contrary, we observed bimodality (Figure 4D) when the SigA binding site was mutated.

When the 124/506B binding site was mutated, miR-124 still upregulated lucifease expression to 240% (p = 0.0030).

When the 148/152A binding site was mutated, miR-148 downregulated reporter gene expression to 47% (p = 0.0049).

When the 124/506A binding site was mutated, miR-124 no longer affected expression of the reporter gene.

In the NFIX promoter (a 234 bps region −404 bps to −171 bps relative to transcription start site), HSF1 binding site was mutated to an NdeI site.