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The published crystal structure of the yeast proteosome in complex with salinosporamide A [25] was examined and the residues proximal to the inhibitor binding site were identified.
Sites matching the putative C57Bl/6 PRDM9 binding site were identified with MAST, using standard parameters.
As is seen with other amyloid-β ligands, one high-affinity and one low-affinity binding site were identified [ 6, 13].
Within this construct a RXRα, two Sp1, a CAC-binding protein and a PPARα binding site were identified using the Transfac database via the online-tools TESS and PATCH.
Similar(56)
A Zn2+ binding site was identified by X-ray fluorescence emission analysis of the CCR2-T4L BMS-681 CCR2-RA-[R] CCR2-T4L BMS-681 CCR2-RA-[R]
Strikingly, a novel potentially SMYD2-specific polyethylene glycol binding site is identified in the CTD domain, implicating possible functions in extended substrate binding or protein protein interactions.
A homology model of the steroidogenic acute regulatory protein (STAR -related lipid tranSTAR -relateddomain of STARD1 was builipidnd transfereSTARTl bindomainite was identified.
For example, WRKY71 for whom a binding site was identified in the OsEULS2 promoter was upregulated upon infection with Magnaporthe grisea (Berri et al. 2009).
Here, the development of a new pharmacophoric binding site descriptor in the spirit of Cavbase [3] is presented: Instead of focussing on ligand features, crucial amino-acid residues within the binding site are identified and represented as a pharmacophore model.
A potential CRP binding site was identified in the promoter region of ler.
The diphosphate binding site was identified in the putative active site of both models in close proximity to N102.
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