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The molecules with a maximum of at least 2 H-bonds with the hinge region at the ATP binding site were considered along with any one of the rings.
Three properties of the binding site were considered: the total number of atoms at 4 Å from its surface, its hydrophobicity, i.e., the fraction of carbon atoms among this total number, and its exposure to the solvent.
Only genes containing both a potential core binding site and a potential half binding site were considered as positive for the presence of a "complete QRE".
The side chains of residues surrounding the binding site were considered flexible.
Promoters overlapping with an ETS binding site were considered as ETS factor bound promoters.
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A binding site is considered to be conserved if its score meets the threshold score for its binding matrix in all 3 species.
Although the TLR4 promoter region has no direct STAT3 binding site, its PU.1 binding site is considered to be one of its main regulatory elements and STAT3 has been shown to be capable of activating PU.1 [51].
A CTCF binding site was considered a constitutive binding site when the same motif site was present in more than 90% of the 55 cell lines.
A binding site was considered to be conserved across the alignment if its score met the threshold score for its binding matrix.
The top four predicted sites proposed by Q-SiteFinder as the putative binding site are considered; a minimum of P-value at this setting is observed (Supplementary Material).
A binding site is considered to be conserved across the alignment results if its score is no less than the threshold score.
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binding site were designed
binding site were labeled
binding site were chosen
binding site were kept
binding site were collected
binding site were mutated
binding site were carried
binding site were made
binding site were predicted
binding site were performed
binding site were retained
binding site were obtained
binding site were generated
binding site were substituted
binding site were validated
binding site were simulated
binding site were searched
binding site were identified
binding site were added
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