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However, the master example of time-resolved monitoring of recruitment and release of cohorts of co-regulatory complexes on a single transcription factor binding site was provided by Metivier and colleagues on the same chromatin region (Metivier et al. 2003).
Further support for the proposed binding site was provided by MD simulations with the R-enantiomer of AR-C155858 which is more than two orders of magnitude less potent at inhibiting MCT1 in the Jurkat cell line (AstraZeneca, unpublished data).
Evidence for the vestibular, or S2, pocket serving as the initial substrate binding site was provided with the dopamine transporter, in which two dopamine molecules were seen to be necessary for substrate translocation through the cell membrane.
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One way to circumvent this problem has been implemented with antibody systems, where contribution to the binding site is provided by two different polypeptides (light and heavy chains).
AFL has a higher preference toward long-chain substrates whose binding site is provided by a hydrophobic tunnel in the C-terminal domain.
Additionally, no information regarding a binding site is provided.
The second shared primer binding site is provided by a HRV 3C protease cleavage site located downstream of purification and solubility enhancing tags for tag removal.
For decades it has been assumed that the face of the agonist binding site is provided by α subunits and the face by β subunits.
A possible explanation for the spatial restrictions of this sensitive Wnt3a binding site is provided by our model of the V337W substitution in Figure 6B.
For each full-length LTR retrotransposon, superfamily, putative lineage, overall length, identity percentage between both LTR sequences, target site duplication (TSD), polypurine tract (PPT) and tRNA binding site are provided, as well as the sequences of the element and of its LTRs.
For small clusters of high sequence similarity and single strains, up to 8 times more discriminating binding sites were provided by the 23S rRNA.
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