Sentence examples for binding site was enriched from inspiring English sources

However, Han et al. demonstrated that radiolabeled resveratrol bound to the rat brain plasma membrane fraction with an apparent affinity of 220±45 nM (∼50 ng/ml) and various polyphenols competed against specific resveratrol binding, suggesting that a common receptor binding site was enriched in the brain plasma membrane [21].

We identified 172 instances in which any miRNA 3'UTR binding site was enriched (p ≤10-4) across these comparisons.

For example the p53 binding site was enriched amongst genes dysregulated by five compounds (K, L, N, P, and Q).

From our microarray data we have seen that P53 binding site was enriched in the upstream of up-regulated genes.

Transcription repressor REST was up-regulated by HIPPI and consequently REST binding site was enriched in the upstream of down-regulated genes (Additional file 4).

The Bellringer/replumless/pennywise binding site is enriched in promoters of genes from multiple distinct expression profiles in cotyledons and leaves.

Thus the current analysis suggests that ER binding site is enriched in conserved estrogen-responsive genes compared to the 'non-conserved' human homologs of zebrafish estrogen-responsive genes that did not overlap with any of the human cancer cell lines.

The web-based platform oPOSSUM3.0 (http://opossum.cisreg.ca/oPOSSUM3) was used for transcription factor binding site analysis [ 28]. oPOSSUM 3.0 detects known transcription factor binding sites in the promoter sequences of co-expressed genes in order to evaluate whether a transcription factor binding site is enriched within the gene set [ 29].

We tested the hypothesis that this same binding site is enriched upstream of ribosomal genes in N. caninum, which is closely related to T. gondii, and to C. parvum which though separate from all the other apicomplexans considered is classed together with T. gondii and N. caninum as an eucoccidioridian.

This analysis selects transcription factors whose binding sites are enriched in ChIP-enriched regions compared to background promoters (see Methods).

Thus, Insm1, Neurod1 and Foxa2 frequently bind in close proximity in chromatin of pancreatic β-cells, and high affinity binding sites are enriched in sites co-occupied by all three factors.