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Loss of the normal LCS6 let-7 binding site was associated with increased transcription and translation of KRAS.
We also observed that the AGGAG motif located in the ribosome binding site was associated with greater mRNA stability.
For intersection with our dataset, Myc binding site was associated with gene's promoter if it was located within 5 kbp from gene's transcription start site (TSS).
Five putative miRNA binding sites were identified, though none was polymorphic: i.e. no putative miRNA binding site was associated with any of the eight SNP alleles.
Eight SNPs have been identified in the promoter and exonic sequences of PRTN3, and a polymorphism in the promoter region of PRTN3 (A-564G), affecting a putative transcription factor binding site, was associated with WG when allele frequencies were compared in 66 cases and 106 controls [ 30].
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The Ile105Val allele and a SNP in the upstream promoter region (SNP1: rs6591255, putative transcription factor 1 binding site) were associated with asthma and wheezing outcomes, an association observed in two cohorts of the CHS recruited in different years.
Our efforts revealed a variant within the first intron of MPZ that resides within a previously described SOX10 binding site is associated with decreased enhancer activity, and alters binding of nuclear proteins.
Several reports have shown that the active structure of serine proteases contains Ca2+-binding site(s), and that the removal of Ca2+ from the strong binding site is associated with a significant reduction in thermal stability [ 30].
Because the directionality of octamer movement is likely determined by the orientation with which ISWI is bound to the nucleosome, i.e., perhaps each binding site is associated with one direction of translocation.
Both in the CM and in the E2T datasets a putative ERR binding site is associated to GATA-3 at a fixed distance of 24 bp in the context of MER41A/B TEs.
These findings are in line with several earlier reports showing that active structure of serine proteases contains Ca2+ binding site(s) and the removal of Ca2+ from the strong binding site is associated with a significant reduction in thermal stability [ 35].
More suggestions(15)
binding site was ligated
binding site was separated
binding site was detected
binding site was defined
binding site was named
binding site was identified
binding site was predicted
binding site was used
binding region was associated
binding site was shown
binding site was mutated
binding site was proposed
binding site was found
binding site was explored
binding site was positioned
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