Sentence examples for binding site to prevent from inspiring English sources

To assess the functional significance of this high-affinity interaction, we used peptide fragments containing the binding site to prevent NLX from binding full-length FLNA in organotypic striatal slice cultures.

On the basis of the second alignment, an additional probe was selected at an alternative binding site to prevent interference with probes at the first binding site.

By starting with a population of ES cells in which integrated provirus has escaped the initial silencing system by virtue of replacement of the primer binding site to prevent binding of ZFP809, we investigated the role of DNMT3L-mediated DNA methylation acquisition in the gradual silencing of active retrovirus.

Most of the known small terminase subunits contain a predicted N-terminal helix-turn-helix (HTH) DNA-binding motif that is not only responsible for the recognition of viral DNA and subsequent initiation of packaging [ 27] but also involved in the specific binding of the cos site to prevent premature DNA release from the pressurized nucleocapsid upon completion of genome packaging [ 40].

Mutation of the site to prevent binding resulted in impaired reporter activity in ERBB2 over-expressing cells [ 10].

Mutation of E236, which is near loop C of the binding site, to aspartate prevents expression of the receptor on the cell surface, and no specific ligand binding can be detected.

Mutation of the essential Lys in the MST3 ATP-binding site to an arginine residue [FLAG MST3 K53R)] prevented the appearance of any 58 kDa FLAG MST3 on exposure of myocytes to calyculin A and the MST3(275–393) mAb epitope was preserved.

To prove whether the regulation of HIF3α is due to direct binding of miR-210-3p miR-210-3p miR-210-3pget sites in the 3'UTR, the predicted binding sites were mutandd miR-485-5p miR-485-5p miR-485-5ponal file 1: Figure S1).

Furthermore, in the structure of Na+-bound outward-facing GltPh we observe opening of HP2 tip, which may facilitate L-asp access to its binding site and prevent the inward movement of the Na+-only bound transport domain, as previously suggested (Focke et al., 2011).

Like antibodies, protein fragments can exert their therapeutic action through antagonizing receptors by inhibition of their ligand binding site(s), or binding to ligands to prevent their interaction with cognate receptor(s).

While highly conserved regions as primer binding sites were avoided to prevent amplification of human DNA, less conserved regions as primer-binding sites may explain the lack of detection of certain mucorales by the ITS-2 assay.