Sentence examples for binding site to activate from inspiring English sources

In particular, is the role of the putative second NADPH binding site to activate the enzyme ?

These stimuli can prompt the active NF- κB (p65 p50 subunits) translocate into the nucleus where it binds with NF- κB-specific DNA-binding sites to activate transcriptionally the expression of several survival genes.

EphA2-null endothelial cells reconstituted with EphA2 mutants lacking these binding sites fail to activate Rac1 GTPase, are defective in cell migration and assembly in vitro, and are unable to incorporate into tumor vasculature in vivo.

Author's Response The role of the putative second NADPH binding site is likely to activate the enzyme.

These data suggest that the NFY binding site is required to activate FPGS gene transcription in lymphoid cells.

Similarly, Durrett and Schmidt (2008) specifically examined the case of pairs of sites and estimated that in Drosophila a pair of mutations can inactivate a binding site and activate another on the time scale of several million years, consistent with empirical observations (Ludwig et al. 1998; Swanson et al. 2011).

Transient transfection of dCas9VP48 with sgRNA complementary to rtTA binding site (sgTetO) activated the TetO::tdTomato reporter in the absence of doxycycline at almost the same efficiency as the positive control.

The −1195 A→G polymorphism creates a c-MYB binding site, which can activate COX-2 expression, and displays a higher promoter activity [15].

A second SAM molecule, thought to bind at the same binding site, is then activated by the reduced [4Fe-4S] clustor to generate a dAdo radical.

The experiments presented in this manuscript allow us to draw three major conclusions: firstly, the dihydropyridine nifedipine and the steroid PS bind to separate binding sites for activating TRPM3 channels.

Thus, three Mirk promoter constructs, each only containing the exon 4 CREB binding site, were activated ~6-fold by wild-type CREB compared with mutant CREB.