Sentence examples for binding site that mediates from inspiring English sources

A C-terminus ubiquitin binding CUE domain identified by Shih et al. [2] as a ubiquitin binding site that mediates intramolecular monoubiquitylation.

Ultra-low-dose NLX co-treatment suppresses opioid tolerance and dependence by preventing these MOR signaling alterations [5], and we recently identified the NLX binding site that mediates its protective effects as a pentapeptide segment in c-terminal FLNA [9].

EEA1 does not contain any identifiable UIMs, but it might have a cryptic ubiquitin binding site that mediates its own ubiquitination.

The C2 domain comprises a C-terminal EFYA motif that is common to all syndecans and constitutes a PDZ domain-binding site that mediates protein protein interactions with a number of binding partners.

TG2 can act either by direct cross-linking or by its GTP-binding site that mediates signal transduction via phospholipase C, focal adhesion kinase and PI3K activation (Mehta et al. 2010).

The purpose of this study was to investigate, in human skin, the possible existence of specific binding sites that mediate the protective action of resveratrol.

These YAP/TAZ phosphorylation events create a 14-3-3 14-3-3 14-3-3that causes the cytoplasmic retention of YAP/TAZ (mediated binding27 phositerylathat of YAP) and a separate phospho-degron that mediates the proteasomal degradation of YAP/TAZ (mediated by Ser381 phosphorylation of YAP).

The CUB domains have a homologous Ca2+-binding site that mediates ionic interactions between protein partners [ 38], similar to that described for the LDL receptor family [ 42, 43].

This phosphorylation site stands within the non-structural loop that links the BH3 and BH4 domains of the protein, but is not directly part of the BH3-binding site that mediates interactions with BH3-only proteins.

Since the underlying cause of this induction is proposed to be linked to a transcriptional mechanism [13] [17], we cloned a proximal sequence of the PGC-1α promoter and analyzed this fragment with stringent computer-assisted analyses to identify candidate transcription factor binding sites that could mediate the AICAR effect.

The promoter region of human OPG contains various putative transcription factor binding sites that may mediate the stimulation of OPG expression by different calciotropic factors [ 7].