Sentence examples for binding site that leads from inspiring English sources

This polymorphism is located within a putative Stimulatory protein 1 (SP1) binding site that leads to a 30% reduction of the PTGS2 promoter activity in vitro [46].

These data are consistent with experimental studies of HIV-1 protease inhibition by zinc and give strong evidence that this is the binding site that leads to inactivation.

For example, the gene RME1 (YGR044C) is expected to have higher expression in this strain of S. cerevisiae relative to the other three species because there is a known variation in RME1's transcription factor binding site that leads to an increase in the gene's expression [ 21].

These rearrangements allow formation of a nucleotide-free motor that is strongly bound to its MT track (Nakata and Hirokawa, 1995), at least in part due to additional contacts formed between loop11 and the MT. Conformational changes at the nucleotide-binding site that lead to Mg-ADP release also appear to prime the kinesin motor domain for Mg-ATP binding.

Or, the other way, a mutation may produce a new transcription factor binding site that will lead to genes being turned on in a type of cell where it wasn't before, leading the cells to be different.

Notably, the C allele of rs5743836 exhibits greater NF- κB-binding affinity because of an additional NF- κB transcriptional binding site that may lead to increased production of proinflammatory cytokines.

In [ 28], an essential binding site from ptc1 promoter, with a single substitution from the consensus GBS sequence, was mutated to investigate the effect of change bases in the expression of a reporter gene, resulting in different non-consensus and low affinity Gli binding sites that could lead to transcriptional activation.

siRNA-mediated knockdown, that increases the mRNA degradation rate 10-fold for 350 credits; iii. a decrease of RBS (ribosomal binding site) activity that leads to a 10-fold decrease in translation rate for 450 credits.

The alteration of the substrate-binding site that is required to accommodate the 2′-amino group leads to a rearrangement of the polymerase active site and a disruption of the coordination shells of the active-site metal ions.

Collagen II remodeling by MMP-13 may result in the uncovering of cryptic integrin-binding sites that may lead to increased cell-matrix adhesion by integrins other than β1 or β2.

It was recently shown that autoregulation of TARDBP involved a 3′′UTR TARDBP binding site that under high TARDBP conditions led to increased intron 6 splicing and RNA polymerase stalling resulting in a shorter TARDBP ORF, V2 TARDBP transcript that is degraded by a nonsense-mediated decay.