Sentence examples for binding site that is from inspiring English sources

It is therefore very likely that OT binds to a common binding site that is located in between those four residues (Arg, Phe, Tyr and Phe) as proposed in the OTR model.

In summary, most quinoxaline compounds examined here show no difference in their affinities at 5-HT3A and 5-HT3AB receptors, and we suggest that these compounds may only bind to the A+A binding site that is found in both receptor types, consistent with all other 5-HT3 receptor-competitive ligands.

The experiments demonstrate that Lamellipodin does not simply tether Ena/VASP proteins to the membrane but also binds directly to actin filaments, via a binding site that is distinct from the site that contacts Ena/VASP.

This led to a model wherein azide binds to the protein at an anion binding site that is near to the vacant sixth coordination position of the nickel and involves interaction with the N H groups of the amides of Asp3 and Cys6, and is near to the OH group of Tyr9, a structure that is in agreement with the crystal structure of the Cl /Br– anion complexes of a Y9F mutant enzyme (see below).

Although this region does not directly bind p53 protein, it contains a p53-dependent transcriptional repression binding site that is necessary for negative regulation of a p53-induced viral-specific DNA enhancer [ 21, 26].

This specificity was explained when we found that doublecortin binds between the protofilaments from which microtubules are built, a previously uncharacterized binding site that is ideal for microtubule stabilization.

The alteration of the substrate-binding site that is required to accommodate the 2′-amino group leads to a rearrangement of the polymerase active site and a disruption of the coordination shells of the active-site metal ions.

Sequence analysis suggested that hAFP contains one conserved Ca2+-binding site that is present in the CTLDs [13].

These include a ligand binding site with stacking and electrostatic interactions similar to many natural nucleotide binding proteins and a zinc-binding site that is structurally analogous to the treble clef zinc binding motif [9], [10].

Moreover, both enzymes apparently have a substrate-binding site that is distinct from the active site and certain nonsteroidal anti-inflammatory drugs known to shift the site of proteolysis by γ-secretase also affect SPP [22].

Furthermore, LPMOs share a conserved copper ion-binding site that is solvent exposed on the planar surface [ 13].