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Hsp90 chaperones contain an N-terminal ATP binding site that has been effectively targeted by competitive inhibitors.
Our genetic data show no support for a derivatized-macrolide binding site that has been proposed to be located further down the tunnel.
Furthermore, in the external aldimine model of N-succinyl-2-amino-6-keto-pimelate, the succinyl group overlaps with a glycerol binding site that has also been identified in both active sites of the Mtb-DAP-AT dimer.
The sigma-1 receptor is a unique non-opioid, non-PCP binding site that has been implicated in many different pathophysiological conditions including psychosis, drug addiction, retinal degeneration and cancer.
The peak in this track is a functional Gli3 binding site that has been experimentally verified.
The one exception is a weak secondary Rev binding site that has been identified adjacent to the high affinity site.
Similar(47)
All promoters contained a core NAC transcription factor binding site that had been predicted from the promoter element analysis of ANAC019 and ANAC092[ 7].
Cerato-platanin domain-containing proteins such as EPL (eliciting plant response-like), Snodprot, swollenins and expansins have a double ψβ-barrel fold and a carbohydrate binding site that have been shown to induce plant defense response [ 55, 56].
We did not explore the importance of the binding site that had been identified previously between residues 205 and 229 of RPSA using synthetic peptides, because these residues are located at the junction between the N- and C-domains [ 15, 38].
This may imply that an early form of the CPA1 antiporters, which must have arisen by gene duplication of an unknown precursor, had a second, symmetrical ion-binding site that has been lost in the course of evolution.
Direct repression by p53 was confirmed using a luciferase reporter vector controlled by the human miR-17-92 miR-17-92 miR-17-92 a promotering site that has been linked to miR-17-92 repression (Yan et al, 2009).
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