The core promoter contains several transcription factor binding sites that facilitate transcription initiation, such as the TATA box, the GC box, Inr [ 1, 3], and the recently discovered MTE [ 4] and DPE [ 5].
While it is plausible that the stretched kinetochores in condensin-depleted chromatin have disoriented microtubule-binding sites that facilitate merotelic attachments, why would such mis-attachments remain uncorrected in metaphase and anaphase?
This may explain why mammals use the POT family homologues PepT1 and PepT2, as coupling peptide transport to the proton gradient appears to facilitate a promiscuous binding site that can adapt to chemically diverse side chain groups more easily than sodium coupled transporters, which require well-defined binding sites for the cation.
FN is an important multifunctional ECM protein, containing an RGD integrin-binding site that facilitates cell binding and migration (Romberger, 1997).
The refined PWM also facilitates in silico identification of novel binding sites that are supported by experimental data.
One proposed that the arginine binding site in WDR5 facilitates its association with MLL1.
Any particular motif might provide specific binding sites for factors that facilitate chromatin access for the recombination initiation factors, resulting in recombination hotspots [ 22, 37].
We previously suggested that disordered segments with different sequences could use their flexibility to bind to a common binding site, thereby facilitating many-to-one signaling [ 35].
Which parameters determine the transition from a flow-facilitating binding site to a flow-facilitating repulsive interaction, and what is the mechanism behind?
Demethylation of this CTCF binding site facilitates binding of CTCF, resulting in decreased expression of PRKCZ.
This results in loss of the promoter binding site, facilitating promoter clearance, and creates a tunnel that surrounds the RNA transcript after it peels off a seven base pair heteroduplex.
