Sentence examples for binding site that enables from inspiring English sources

The most highly conserved binding site is that of the HIV-1 protease, likely due to the large volume and enclosed shape of the catalytic binding site that enables consistent identification by fpocket and robust detection of similarity by SiteHopper, respectively.

[18, 19] The formation of the encounter complex reduces the dimensionality of the diffusional search for the binding site that enables rapid ET. [1] It has been suggested that the population balance between the encounter state and the well-defined state depends on whether rapid ET can occur in encounter-state orientations.

The S. cerevisiae Atg19 cargo receptor contains multiple low-affinity Atg8 binding sites that enable it to selectively and tightly bind to membrane-localized Atg8 (Sawa-Makarska et al., 2014).

AKAPs also contain unique localization signal(s) which are responsible for AKAP targeting to sub-cellular compartments, and in many cases, AKAPs also contain enzyme-binding sites that enable the formation of multi-protein signaling complexes [ 16, 17].

Upon binding to F-actin, Vt undergoes a conformational change that exposes a cryptic dimerization site that enables F-actin bundling.

We next investigated the potential interaction sites that enable ubiquitinPhospho-Ser65 binding and activation of Parkin E3 ligase activity.

The binding site that was considered for the VS was not the ATP site, but the allosteric site identified experimentally.

On the other hand, the allosteric ligand binding sites that developed during evolution by mutations in the C-terminus enable fine-tuning of the regulatory enzyme by the elevated levels of specific downstream metabolites.

On the other hand, the allosteric ligand binding sites that developed because of mutations in the C-terminal region enable fine-tuning of the regulatory enzyme in response to elevated levels of specific downstream metabolites.

High-affinity binding of NikR to its operator DNA can be achieved when the RHH domains adopt a structurally observed down-cis conformation that enables these domains to make site-specific contacts with nucleotides in the major grooves at the DNA binding sites (9, 10).

The large number of additional, lateral binding sites sometimes creates large cooperativity effects that enable filaments to bind with extreme affinity to their partner, even if the individual binding energies, per subunit, are rather small.