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SRs were initially identified by Goldstein et al. with the discovery that macrophages take up acetylated LDL through a specific surface binding site that does not recognize native LDL [23].
Notably, pRb holds a second alternate E2F1-specific binding site that does not interfere with E2F1's transactivation domain.
This drug destabilizes microtubules by interacting with a binding site that does not overlap with those of known microtubule-destabilizing agents like vincristine or colchicine [ 137, 138].
A predicted binding site that doesn't fall within these 4 cases is labelled as a FP, while a missed spike-in DNA segment constitutes a FN.
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To encompass potential protein ligand binding sites that do not have ligands known to bind, we have incorporated fpocket cavity detection software and assessed the impact of this inclusion on BSC performance.
Despite the high overlap of RAD21 and CTCF binding, we also identified 4087 (26.7%) RAD21 binding sites that did not co-localize with CTCF in ESCs (Fig. 1A and Table S2).
This allowed our models to include the 10% binding sites that do not have p63 DNA-binding motif.
10 Most enriched DNA motifs found in CUX1 binding sites that do not contain the ATCRAT CUX1 consensus.
This allows the study of mutations of binding sites that do not knock components out but change their interactions [ 45].
Previous studies have shown that global bacterial transcription factors can recognize multiple non-canonical binding sites that do not conform to a consensus site [ 50, 51].
Accordingly, there is a need to extend predictors to include 14-3-3 14-3-3 14-3-3 that do not conform to Mode I binding and to tesitese signal multhatexing hypothesis.
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