Sentence examples for binding site that confer from inspiring English sources
Comparative modelling and docking studies were carried out to understand the structural differences of the binding site that confer this characteristic property.
This structure determination was undertaken to establish the stereochemical features in the antibody binding site that confer specificity for cocaine, and as part of an ongoing project to understand the rules that govern molecular recognition.
To assess the number of mutations at the binding site that confer GE resistance and thereby pose a threat to effective antibiotic treatment, Ebright and colleagues used a technique called saturation mutagenesis.
Our data strongly support the notion that tRNA gene transcription in eukaryotes is modulated by composite TFIIIB binding sites that may confer responsiveness to variation in TFIIIB activity and/or concentration.
We find that human and chimp FOXP2 have similar binding sites that are distinct from previously suggested consensus binding sites.
Taken together, the above results using transient transfection assays demonstrate that the Mitf-M ATF binding site can confer response to EWS/ATF1 but that surprisingly, the Mitf-M promoter is refractory to EWS/ATF1, even under conditions (in melanocytes) in which the Mitf-M promoter is amenable to activation by cAMP.
The finding that anchored kinases are refractory to active site inhibitors has important ramifications for drug discovery as endogenous binding partners that confer resistance to ATP analog inhibitors.
Crocker, J. et al. Low affinity binding site clusters confer hox specificity and regulatory robustness.
The kinetics of inhibition by ketoclomazone suggested that ketoclomazone binds to an unidentified inhibitor-binding site that differs from both the pyruvate-binding site and the D-GAP-binding site on DXP synthase.
For example, a binding site mutation that interacts directly with the drug molecule might confer primary drug resistance [ 13- 15].
This study identifies the first mammalian βI-tubulin mutation that specifically increases sensitivity to PLA, and reports mutations at PLA and LAU binding site residues that can either reduce microtubule stability or impair drug tubulin binding, conferring resistance to these microtubule-stabilizing agents.
