Sentence examples for binding site that competes from inspiring English sources

First, it is conceivable the variant weakens the affinity for SOX10 and/or creates a novel protein binding site that competes with SOX10.

It is possible, however, that they may serve as decoy sites that compete with the key binding sites for phosphorylation by the targeting kinase [46].

JAI-51 is able to compete with colchicine for the same binding site that induces inhibition of tubulin polymerization.

Since ConA is a tetramer, it presents multiple binding sites that can aggregate with these multivalent competing ligands over time.

This tetrapeptide binds XIAP (Wu et al, 2000) and competes with the same binding sites that are responsible for the interaction with caspases (Liu et al, 2000).

One problem with overexpressing skelemin C2 is that it would saturate the skelemin binding sites on integrins and not only block endogenous skelemin binding but also the association of other integrin binding partners that compete for the skelemin binding site.

Oxamate, an inhibitor of LDH that competes with pyruvate for its binding site on the enzyme, induced apoptosis in MM cells.

Roscovitine is a 2,6,9-substituted purine analogue that competes with ATP for the active binding site on CDKs (MacCallum et al., 2005).

For example, a transcriptional suppressor protein that competes with a transcriptional activator for the same binding site could result in decreased activation through increased methylation [13].

Almost all the 4-anilino quinazoline based EGFR small molecule kinase inhibitors that compete for ATP binding site contains this functional group (R2NH).

Brk accomplishes this via repressor complexes containing Teashirt that compete for enhancer binding sites with Arm/dTCF activation complexes [29].