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These YAP/TAZ phosphorylation events create a 14-3-3 14-3-3 14-3-3that causes the cytoplasmic retention of YAP/TAZ (mediated binding27 phositerylathat of YAP) and a separate phospho-degron that mediates the proteasomal degradation of YAP/TAZ (mediated by Ser381 phosphorylation of YAP).
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The binding site that was considered for the VS was not the ATP site, but the allosteric site identified experimentally.
Other studies have shown that the CDA '5 flanking region contains numerous potential transcription factor binding sites that can cause variations in transcription [ 18].
Our approach, in contrast, starts with an analysis of the diphosphate binding sites that is used as a basis for a clustering to avoid statistical falsification caused by imperfect grouping.
It also suggests that some positive Wnt target genes such as TACSTD2 and SEMA3F, which were not over-expressed when we activated Wnt in the absence of new protein synthesis may contain TCF4-binding sites that are not involved in causing increased gene expression in vivo.
When a new TF with the same DNA-binding specificity is generated by gene duplication, new pairs of TFs and their target genes also arise, causing harmful "cross lines" through the DNA-binding sites that were previously neutral features.
Our data extend these findings by showing that the OCT4 binding site mutation caused incomplete switching from paternal to maternal ICR1 methylation imprint, and that upon further maternal transmission, methylation of the incompletely demethylated variant ICR1 allele was further increased.
Using UV visible spectrophotometry, we show that the removal of K+ binding site causes substantial changes in spin states of both the ferric and ferrous forms.
Utilization of the symmetric Tanimoto similarity coefficient causes an inherent size matching to exist between pairs of binding site patches that show high levels of structural similarity.
It has been observed that single nucleotide polymorphisms (SNP) within a miRNA binding site can cause significant phenotypic changes [ 14].
The binding of pepJIP1 to the JIP1 binding site on JNK1 causes a small conformational change at the ATP site.
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