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The MyoD promoter contains a highly conserved TRE binding site that can bind TR in vivo [41].
The broad substrate specificity of the sulfotransferase enzymes may be linked to three highly flexible loops flanking the catalytic binding site that can adapt to various ligands.
Aside from type I IFNs, TNF mRNA contains a binding site that can be targeted by miR-125b in mouse RAW 264.7 macrophages [ 40].
In addition, FAPP2 has a glycolipid transfer activity, which is abolished by a mutation in the glycolipid binding site that can be inferred from the homology with GLTP [10].
The current structures and functional data reveal a binding site that can accommodate peptides in different orientations that helps to explain the broad substrate specificity characteristic of this pharmaceutically relevant transporter family.
Here we sought to use the exploratory potential of mAb to identify a binding site that can block the polymerization of Z α1-antitrypsin without loss of inhibitory activity.
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The GFP-tagged mRNA contains eight MS2 binding sites that can each bind a maximum of two (45 kDa) GFP-fusion proteins.
The value of the additional structural information on adsorbate binding sites that can be obtained from infrared reflection-absorption spectroscopy (IRAS) as well as from potentiodynamic STM imaging tactics is emphasized.
Streptavidin, with relatively larger molecular weight, has four binding sites that can react to biotin, with very low molecular weight; streptavidin has a very high affinity with biotin.
By using unique overhangs, one can easily extend the number of shuffled genetic elements that can be ligated in a controlled fashion to obtain promoters with a larger number of transcription factor binding sites that can be shuffled in a combinatorial fashion.
They are artificially created ligand binding sites that can selectively recognise a target molecule.
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