Sentence examples for binding site that allows from inspiring English sources

In the ttGBP binding site, this groove is partially filled by two loops and an α-helix, which create a buried binding site that allows binding of only monosaccharides.

Mutation of one or more of these residues generates a "pocket" in the ATP binding site that allows the mutant kinase, but not other cellular kinases, to utilize analogs of ATP with bulky substituents synthesized onto the N-6 position.

The different ligand geometries in the identical domains in the crystal structure protomers also suggest a degree of plasticity in the aromatic side chain arrangements at the binding site that allows conformational adaptation to ligand motions.

The experiments revealed a vesicle protein called Upa1 that contains a new type of binding site that allows Upa1 to bring an important RNA-binding protein to the surface of vesicles.

These observations suggests that the primary, high level mechanisms of 14-3-3 14-3-3 14-3-3ificity are a broad binding site that allows multiple trajectoriespecificityefore interareion with different residues) and side chain rearrangement to accommodate different peptide sequences.

Here, we report that the H7N9 HA shows limited binding to human receptors; however, should a single amino acid mutation occur, this would result in structural changes within the receptor binding site that allow for extensive binding to human receptors present in the upper respiratory tract.

Furthermore, we describe a second, previously unreported ligand-binding site that allows a simple mechanistic explanation for the allosteric effects reported by Djuranovic et al (2010).

ZO-2 contains several protein binding sites that allow it to function as a scaffold that clusters integral, adaptor and signaling proteins.

The regulatory components of cyclic nucleotide-dependent protein kinases each harbor two tandem cyclic nucleotide binding sites that allow allosteric and cooperative control of kinase activity.

Careful bioinformatic and experimental analysis of promoters of ORs expressed in other tissues could reveal recently arisen transcription factor binding sites that allow novel regulatory control in non-olfactory tissues.

These enzymes may employ two means to promote protonation of the alkoxide intermediate: a potential proton donor or hydrogen-bonding group within the active site (His271 in PLR; Ser263 and Ser267 in PCBER), and a more open binding site that may allow access to the intermediate by bulk water.