Sentence examples for binding site that accommodates from inspiring English sources

The P1 pocket in the DR4 binding site that accommodates the side chain of Phe263 in 1 is a large, deep and mainly lipophilic pocket (Figure 2b).

As correctly stated by the reviewers, a typical SF2 helicase contains a bipartite nucleic acid binding site that accommodates up to 8 nucleotides (or base pairs) of DNA or RNA.

Whereas typical SF2 helicases contain a bipartite nucleic acid binding site that accommodates up to 8 nt (or bp) of nucleic acid (Singleton et al., 2007; Fairman-Williams et al., 2010; Beyer et al., 2013), XPD and related 5′ 3′, FeS-containing helicases feature additional contacts with the translocating strand beyond this canonical binding site.

This study reveals that polyspecificity in the POT family is likely to have arisen in part through the evolution of a binding site that can accommodate peptide ligands in at least two different binding modes.

The current structures and functional data reveal a binding site that can accommodate peptides in different orientations that helps to explain the broad substrate specificity characteristic of this pharmaceutically relevant transporter family.

The subsequent diversification of this clade appears to have involved extensive adaptation of the binding site that originally contained the 2Fe-2S cluster for accommodating a diverse set of new ligands.

The di-phosphorylated peptide is accommodated on a binding site that involves the top surface of the 8-bladed WD40 β-propeller domain of Fbw7 (Hao et al., 2007 ).

Also in this case, a di-phosphorylated peptide is accommodated on a binding site that involves the top surface of the 7-bladed β-propeller domain of β-TrCP (Wu et al., 2003 ).

These observations suggests that the primary, high level mechanisms of 14-3-3 14-3-3 14-3-3ificity are a broad binding site that allows multiple trajectoriespecificityefore interareion with different residues) and side chain rearrangement to accommodate different peptide sequences.

The IFNAR1 gene that was present in amniote ancestors already had two D200 allowing the building of receptor complexes with different binding sites that could accommodate the diversification of the ligands [ 18, 27, 37, 38].

Electron density maps and FANCI-DNA crystals have revealed that the FANCD2/FANCI surface includes two sets of double- (dsDNA) and single- strand DNA (ssDNA) binding sites that could accommodate a replication intermediate comprising two converging forks at a crosslink (Fig.  1).