Sentence examples for binding site suggesting that from inspiring English sources
Nucleosomes of African green monkeys are also preferentially positioned but do not depend on the canonical CENP-B binding site, suggesting that histone-DNA sequence affinities or other proteins may influence the placement of nucleosomes [ 17- 22].
The how promoter also contains a putative dE2F binding site suggesting that Rbf1 and dE2F2 could bind this region.
However, the SNP lies within a canonical half-CRE binding site, suggesting that this region normally can bind CREB, or a related transcription factor, and thereby influence splicing, transcription rate, or initiation site.
The identified sequence, however, lacks a canonical homeobox binding site, suggesting that either (1) Arx can bind directly to sequences other than canonical homeobox binding sites or (2) Arx forms heterodimeric transcriptional complexes with non-homeobox or homeobox transcription factors that recognize a variant of the canonical homeobox binding site.
Kitzing et al. (2001) observed that NADPH binds in or near the substrate (5-enolpyruvylshikimate 3-phosphate) binding site, suggesting that NADPH binding to bifunctional CSs is embedded in the general protein structure, and a special NADPH binding domain is not required to generate the intrinsic oxidoreductase activity.
Triclabendazole, closantel and emodepside bound with good affinities to different sub-sites in the inner chamber, partially overlapping with the ML binding site, suggesting that they could compete for Cel-Pgp-1-mediated ML transport.
Thus, consideration of only the binding sites suggests that genes with similar binding properties are present in both species and that both humans and mice can detect Iva (possibly with similar capacity), in agreement with the finding of O'Connell et al. To date, the functional variability within and between OR gene repertoires has been assessed by considering overall protein similarity [7], [14].
The finding that 3/4 of the overrepresented motifs upstream of these late-peaking genes are potential ApiAP2 binding sites suggests that ApiAP2 proteins are important regulators in the later stages of the parasite's intracellular life cycle.
Our previous studies on rice miRNAs and miRNA binding sites suggested that positive selection and nucleotide mutations play an important role in co-evolution of miRNAs and their targets [ 18, 19].
The identification of a consensus sequence in over half of PARP3-bound sequences that matches part of the REST binding site suggests that PARP3 could interact with many of its target sequences through another transcriptional regulatory complex comprising REST.
An in silico search for inclusion of this polymorphism in a putative ESE for SRp40 binding site suggests that rs3790261 may affect the posttranscripional regulation of SLC24A3 mRNA, thus representing a RNA splicing signal.
