Sentence examples for binding site such that from inspiring English sources

The large volume of the HIV-1 protease binding site, such that each pharmacophoric pseudocenter contributes less to the overall similarity, may contribute to the homogeneity of this conserved cluster.

Generally, long MD calculation times are required for successful navigation of the ligand into the binding site such that the computational time necessary for accurate docking of a ligand may be prohibitive in practice.

The conformational change restrains the vacant binding site such that its affinity for binding the second ligand is reduced.

The C2 and C3 regions associate to form the CD4 binding site such that mutations in amino acid at positions 267Q in C2 and 368R in C3 abrogate gp120 binding to CD4 [26], [26].

HSP72 has only a single peptide binding site such that the Sm equals 1 (28).

Grid points were generated around the catalytic pocket to cover the entire ligand binding site, such that the compound to be docked can move freely within it.

Is there a division of labor between different CTCF binding sites, such that some govern insulation and others replication timing patterns?

For example, mutations that alter transcription factor binding sites such that binding efficiency is reduced are hypothesized to lead to the down regulation of gene transcription, but the environments in which such down regulation will improve fitness are unknown.

In the absence of selection, fixation of random mutations will tend to decrease the strength of binding sties [ 19, 20], whereas purifying selection will tend to preserve binding sites, such that the effects of subsequent fixations will cancel out [ 18].

The diffusion coefficient has an associated correlation time τm that describes the time for diffusion between active binding sites, such that Deff(T)≈ ε/(4 τm), where ε is the thickness of the adsorbed surface layer.

Observation of fewer than three contigs per amplicon probably indicates either an insufficient number of HSVs present within the sequenced region to decompose the contigs into individual haplotypes, or substantial divergence between sub-genomes in the primer binding sites, such that not all sub-genomes were initially amplified.