Sentence examples for binding site spanning a from inspiring English sources

This regulatory construction, involving a GTPase binding site spanning a flexibly tethered arm and the inhibitory module, is observed in many autoinhibited effectors of Ras superfamily GTPases, suggesting evolutionary pressure for this design.

These results indicate that the binding site spanning a region of 110 bp (−390 to −280) may include the potential TREs.

We identify promoter sequences and CTCF binding sites spanning a region from 61,282.5 kb to 61,283.5 kb, ~1 kb upstream of the predicted 5' end of pri-let-7i.

Previous studies have shown that the rate of PA assembly is accelerated in the presence of LFN [16], which is believed to bridge a binding site spanning the surface of a PA dimer [37].

All NLSs bind to the major binding site, spanning armadillo repeats 1 4, and some also have a small additional contribution from the minor site, spanning repeats 6 8.[ 8] TPX2, however, binds primarily to the minor site of importin-α, thereby offering an opportunity for selectivity.

Our structural, biophysical and cellular data, map Fz4 and putative Lrp5/6 binding sites to distinct patches on Norrin, and reveal a GAG binding site spanning Norrin and Fz4CRD.

The dPRL-332luc3mutHox construct mutated the Hox binding site spanning −232 to −236 from TTAT to GCGC using the QuickChange site directed mutagenesis kit (Stratagene, Texas USA).

ARIP3 entails 572 amino acid with three functionally characterized domains [13], [14]: 1) The SAP (SAF-A/B, Acinus PIAS) domain from aa 11 45 that may be a DNA binding site; 2) The RING domain from aa 347 388, responsible for the ligase function; 3) The androgen receptor binding site spanning aa 443 548.

Authenticity of these complexes were established by competition analyses using 100 and 200× (Figure 2B, lanes 2 and 1, respectively) molar excess of oligonucleotides corresponding to the putative AP-1 binding site spanning −647 to −657 of the hres gene promoter.

On reflection we suspect that because the GAG binding site spans Norrin and Fz4CRD, the inhibitory effects of separate Norrin-SOS binding and Fz4CRD SOS binding events blocking formation of Norrin-SOS Fz4CRD (similar to in our SOS inhibition assay; Figure 7 figure supplement 1D) may cancel out any stabilizing contribution to complex formation in these in vitro measurements.

Both strands of each promoter were scanned for putative binding sites (spanning the transcriptional start site from 1000 bp upstream to 200 bp downstream).